Samantha godinez valenciano biography of rory
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Abstract
The Mexico City Prospective Study is a prospective cohort of more than 150,000 adults recruited two decades ago from the urban districts of Coyoacán and Iztapalapa in Mexico City1. Here we generated genotype and exome-sequencing data for all individuals and whole-genome sequencing data for 9,950 selected individuals. We describe high levels of relatedness and substantial heterogeneity in ancestry composition across individuals. Most sequenced individuals had admixed Indigenous American, European and African ancestry, with extensive admixture from Indigenous populations in central, southern and southeastern Mexico. Indigenous Mexican segments of the genome had lower levels of coding variation but an excess of homozygous loss-of-function variants compared with segments of African and European origin. We estimated ancestry-specific allele frequencies at 142 million genomic variants, with an effective sample size of 91,856 for Indigenous Mexican ancestry at exome variants, all available through a public browser. Using whole-genome sequencing, we developed an imputation reference panel that outperforms existing panels at common variants in individuals with high proportions of central, southern and southeastern Indigenous Mexican ancestry. Our work illustrates the value
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Author Correction: Genotyping, sequencing and analysis of 140,000 adults from Mexico City
Author information
These authors contributed equally: Andrey Ziyatdinov, Jason Torres, Jesús Alegre-Díaz
These authors jointly supervised this work: Aris Baras, Michael R. Hill, Jonathan R. Emberson, Jonathan Marchini, Pablo Kuri-Morales
Deceased: Gary Whitlock
Authors and Affiliations
Regeneron Genetics Center, Tarrytown, NY, USA
Andrey Ziyatdinov, Joshua Backman, Joelle Mbatchou, Sheila M. Gaynor, Tyler Joseph, Yuxin Zou, Daren Liu, Jeffrey Staples, Razvan Panea, Alex Popov, Xiaodong Bai, Suganthi Balasubramanian, Lukas Habegger, Rouel Lanche, Alex Lopez, Evan Maxwell, Marcus Jones, Amy Damask, Nan Lin, Charles Paulding, Eric Jorgenson, William Salerno, John Overton, Jeffrey Reid, Timothy A. Thornton, Gonçalo Abecasis, Gonçalo Abecasis, Adolfo Ferrando, Michael Cantor, Giovanni Coppola, Andrew Deubler, Aris Economides, Katia Karalis, Luca A. Lotta, Lyndon J. Mitnaul, John D. Overton, Jeffrey G. Reid, Alan Shuldiner, Katherine Siminovitch, Christina Beechert, Erin D. Brian, Laura M. Cremona, Hang Du, Caitlin Forsythe, Zhenhua Gu, Kristy Guevara, Michael Lattari, Alexander Lopez, Kia Manoochehri, Manasi Pradhan, Raymond Reynoso, Ricardo Schiavo, Maria Sotiro
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University of Nevada, Las Vegas (UNLV) Ordinal commencement program
MONDAY,
ECEMBER 20, 2004
Commencement
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Lincoln OF NEVADA LAS VEGAS
UNLV ADMINISTRATION
Carol C. Harter, President
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